Process of isolating vinblastine from the plant catharanthis ros

Details Process of isolating vinblastine from the plant catharanthis ros Process of isolating vinblastine from the plant catharanthis ros

1986-10-23

1988-06-07

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D51904

Patent

active

047497874

ABSTRACT:
This invention relates to a chemical process of producing an antitumor alkaloid. More particularly, it relates to a method of isolation of vinblastine from Catharanthus roseus, comprising the steps of: extracting C. roseus leaves with an acidified aqueous solution; raising the pH and extracting an alkaloid mixture with an organic solvent; chromatographing a solution of the alkaloid mixture over dextran and silica gel columns to obtain vinblastine containing fractions for isolation.

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patent: 4209443 (1980-06-01), Jovanovics et al.
Ciulei, Chemical Abstracts, vol. 71, 128620k (1969).
Renaudin, Chemical Abstracts, vol. 103, 210185k (1985).

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