Dopamine-beta-hydroxylase inhibitors

Details Dopamine-beta-hydroxylase inhibitors Dopamine-beta-hydroxylase inhibitors

1987-01-08

1988-06-07

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514397, 548318, 548336, A61K 31415, C07D40906

Patent

active

047497173

ABSTRACT:
Potent dopamine-.beta.-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.

REFERENCES:
patent: 4634711 (1987-01-01), Kaiser et al.
Chemical Abstracts 100:85629t(1984)[Belgodere, E., et al., Heterocycles 1983, 20(10), 2019-23].
Chemical Abstracts, 102:132034y(1985)[EP 125,033, Frazee et al., 11/14/84].
Blicke, F. in Thiophene and its Derivatives by H. D. Hartough, Interscience, New York, 1952, p. 29.
Bargar, T., et al., J. Med. Chem. 29:315 (1986).

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