Immunosuppressive peptides

Details Immunosuppressive peptides Immunosuppressive peptides

1986-08-01

1988-06-07

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3702, C07K 710

Patent

active

047496851

ABSTRACT:
Immunosuppressive peptides having glycosylation inhibiting factor activity are provided. The peptides include the following sequence and its homologs: ##STR1##

REFERENCES:
Akasaki et al., "Immunosuppressive Effects of Glycosylation Inhibiting Far on the IgE and IgG Antibody Response" The Journal of Immunology, vol. 135, pp. 3172-3179 (1986).
Wallner et al., "Cloning and Expression of Human Lipocortin, a Phospholipase A.sub.2 Inhibitor with Potential Anti-Inflammatory Activity" Nature, vol. 320, pp. 77-81 (1986).
Cloix et al., "Characterization and Partial Purification of `Renocortins`: Two Polypeptides Formed in Renal Cells Causing the Anti-Phospholipase-Like . . . " Br. J. Pharmac., vol. 79, pp. 313-321 (1983).
Hirata et al., "Identification of Several Species of Phospholipase Inhibitory Protein(s) by Radioimmunoassay for Lipomodulin" Biochem. Biophys. Res. Comm., vol. 109, pp. 223-230 (1982).
Ishizaka, K., "Regulation of IgE Synthesis" Ann. Res. Immunol., vol. 2, pp. 159-182 (1984).
Hirata, F. & Iwata, M., "Role of LipoModulin, a Phospholipase Inhibitory Protein, in Immunoregulation by Thymocytes" The Journal of Immunology, vol. 130, pp. 1930-1936 (1983).

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