N-(Lower-alkyl)-N'-[5-(pyridinyl)-2-pyridinyl]ureas and cardioto

Details N-(Lower-alkyl)-N'-[5-(pyridinyl)-2-pyridinyl]ureas and cardioto N-(Lower-alkyl)-N'-[5-(pyridinyl)-2-pyridinyl]ureas and cardioto

1982-09-03

1984-05-15

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546257, C07D21322, A61K 3144

Patent

active

044487800

ABSTRACT:
N-R.sub.1 -N-(6-R-5-PY-2-pyridinyl)ureas, where R.sub.1 is lower-alkyl, R is hydrogen or lower-alkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, or acid-addition salts thereof. Said compounds (I) or pharmaceutically acceptable acid-addition salts thereof are useful as cardiotonic agents. The preparation and cardiotonic use of said compounds are shown.

REFERENCES:
patent: 4276293 (1981-06-01), Lesher et al.
patent: 4297360 (1981-10-01), Lesher et al.
patent: 4317827 (1982-06-01), Lesher et al.
patent: 4331672 (1982-05-01), Lesher et al.
D. A. Inoyatova et al., [Chem. Absts. 74, 125,360b (1971); Tr. Samarkand. Gos. Univ. 1969, No. 167, 173-174 (Russ.) from Ref. Zh., Khim 1970, Abstr. No. 5Zh482].
Boehmer [C. A. 30, 59504 (1936); Rec. Trav. Chim. 55, 379-391. (1936)].

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