Substituted 1,2,5-thiadiazole derivatives

Details Substituted 1,2,5-thiadiazole derivatives Substituted 1,2,5-thiadiazole derivatives

1981-06-23

1983-04-19

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2602444, 2602455, 424246, 42424851, 424250, 424263, 424267, 424270, 544 587, 544 82, 544121, 544130, 544131, 544134, 544357, 544364, 544367, 546187, 546193, 546209, 546256, 546277, C07D28510

Patent

active

043806392

ABSTRACT:
Histamine H.sub.2 -antagonists of the formula ##STR1## wherein p is 1 or 2; R.sup.1 is hydroxy, amino, substituted amino or a 5- to 9-membered fully saturated nitrogen-containing heterocyclic ring attached via its nitrogen atom; m is an integer of from 0 to 2; n is an integer of from 2 to 4; Z is sulfur, oxygen or methylene; and A is an optionally substituted phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl ring; and nontoxic pharmaceutically acceptable salts, hydrates, solvates or N-oxides thereof are novel anti-ulcer agents. Intermediates and processes for their preparation are disclosed.

REFERENCES:
Heterocycles, vol. 16, pp. 1561-1568 (1981).
J.A.C.S., vol. 104, pp. 1375-1380 (1982).
Wen et al., J. Org. Chem., vol. 40, pp. 2743-2748 (1975).

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