Chemical compounds

Details Chemical compounds Chemical compounds

Filed on

1981-06-23

Date issued

1983-04-19

Examiner

Lee, Mary C.

Patent Class

Organic compounds -- part of the class 532-570 series

SubClass

Organic compounds

SubSubClass

Heterocyclic carbon compounds containing a hetero ring...

Other Related Categories

2602455, 424246, 42424851, 424250, 424263, 424267, 424269, 544 60, 544134, 544367, 546193, 546209, 546256, 546277, 548131, C07D28510

Type

Patent

Status

active

Patent number

043806384

Description

ABSTRACT:
Histamine H.sub.2 -antagonists of the formula ##STR1## wherein p is 1 or 2; R.sup.1 is hydroxy, amino, substituted amino or a 5- to 9-membered fully saturated nitrogen-containing heterocyclic ring attached via its nitrogen atom; m is an integer of from 0 to 2; n is an integer of from 2 to 4; Z is sulfur, oxygen or methylene; and A is an optionally substituted phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl ring; and nontoxic pharmaceutically acceptable salts, hydrates, solvates or N-oxides thereof are novel anti-ulcer agents. Intermediates and processes for their preparation are disclosed.

REFERENCES:
patent: 3247193 (1966-04-01), Menzl
patent: 3642811 (1972-02-01), Vorreither et al.
Wen et al.; J. Org. Chem. vol. 40, pp. 2743-2748, (1975).
Carmack et al.; Organic Preparations and Procedures, vol. 1, pp. 255-258, (1969).

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