Intermediates and processes in the preparation of 5-oxygenated H

Details Intermediates and processes in the preparation of 5-oxygenated H Intermediates and processes in the preparation of 5-oxygenated H

1988-09-29

1990-05-01

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549292, 544 584, 544 69, 544149, 544229, 544374, 546 14, 546206, 548406, 548517, C07F 718

Patent

active

049219740

ABSTRACT:
This invention relates to novel intermediates and novel processes for their preparation where said intermediates are useful in the preparation of 5'-oxygenated derivatives (I) of lovastation and analogs thereof at the 8'-acyl side chain and 6'-position of the polyhydronaphthyl ring. Derivatives (I) and analogs thereof are useful in treating hypercholesterolemia. ##STR1##

REFERENCES:
patent: 4588715 (1986-05-01), Damon, II
patent: 4604472 (1986-08-01), Ide et al.
patent: 4710513 (1987-12-01), Willard et al.
patent: 4733003 (1988-03-01), Ide et al.

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