Method for the preparation of imidazoles

Details Method for the preparation of imidazoles Method for the preparation of imidazoles

1988-12-15

1990-05-01

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548346, C07D23358

Patent

active

049219693

ABSTRACT:
This invention discloses an improved method for preparation of imidazoles without isolation of the imidazoline intermediate which comprises reacting a diamine with carboxylic acid and heating the mixture at a temperature of 140.degree.-300.degree. C. at a pressure of subatmospheric to about 10 atm to form an amide, passing the amide over a nickel-containing catalyst at a temperature of 180.degree. C. to 250.degree. C. and a pressure of atmospheric to 200 psig and isolating the imidazole.

REFERENCES:
patent: 2847417 (1958-08-01), Erner
patent: 3152998 (1964-10-01), Moss
Chemical Abstracts, 70:28867g (1969) [N. Sawa, Nippon Kagaku Zasshi 1968, 89(9), 868-72].

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