Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-04-30
1993-08-24
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31445
Patent
active
052389456
ABSTRACT:
Disclosed is a method of treating psychoses in human beings, comprising the step of administering an effective amount of the compound, ##STR1## or a pharmaceutically acceptable salt thereof, to a patient in need thereof.
Said compound selectively blocks dopamine neurones in the ventral tegmental area of the brain, substantially without blocking the dopamine neurones in the substantia nigra pars compacta and, therefore, is free from the extrapyramidal side effects of common neuroleptics.
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patent: 5112838 (1992-05-01), Perregaard et al.
Skarsfeldt, T., et al., Eur. J. Pharmacol. 182:613-14 (1990).
"Current CNS Patents", vol. 1 No. 10 for Dec. 1990--eight (8) pages including especially pp. 653 and 654 relating to Sertindole, a highly selective atypical neuroleptic.
"The Positive-Negative Dimension in Schizophrenia: Its Validity and Significance", Psychiatric Developments 2, pp. 79-80; Stanley R. Kay and Lewis A. Opler; Oxford University Press (1987).
Perregaard Jens
Skarsfeldt Torben
H. Lundbeck A/S
Hollinden Gary E.
Hollrah Glennon H.
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