Hydrolytic stabilizer for unstable organic ions

Details Hydrolytic stabilizer for unstable organic ions Hydrolytic stabilizer for unstable organic ions

1992-07-13

1993-08-24

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536103, 604 51, A61K 3170, C08B 3716

Patent

active

052389278

ABSTRACT:
Storage-stable aqueous solutions of hydrolytically unstable organic ionic compounds and cyclodextrins, which cyclodextrins are capable of forming hydrolytically stable inclusion complexes with the ionic compounds. Storage-stable rapidly solvated organic ionic inclusion complexes of hydrolytically unstable organic ionic compounds and cyclodextrins, which cyclodextrins are capable of forming hydrolytically stable inclusion complexes with the ionic compounds. Systems for rapidly administering aqueous solutions effective in the treatment of organophosphorus toxin nerve poisoning to a mammal in need thereof combining a storage-stable aqueous solution of an inclusion complex of a hydrolytically unstable quaternary pyridinium oxime or aldoxime compound capable of reactivating carboxy, choline and esterases inhibited by the organophosphorus toxins and a cyclodextrin capable of forming a hydrolytically stable inclusion complex with the quaternary pyridinium compounds, and means for rapidly administering the aqueous solution. Systems for rapidly administering aqueous solutions effective in the treatment of organophosphorus toxin nerve poisoning combining the inclusion complex with means for rapidly solvating and administering the inclusion complex.

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