Tetrahydrofuranyl substituted ethers

Details Tetrahydrofuranyl substituted ethers Tetrahydrofuranyl substituted ethers

1984-05-10

1985-06-04

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549214, 549365, 549448, 549462, 549498, 549501, 549502, A61K 3134, C07D30716

Patent

active

045215391

ABSTRACT:
Tetrahydrofuranyl substituted ethers are provided having the structural formula ##STR1## wherein A is (CH.sub.2).sub.2, CH.dbd.CH or a single bond, m is 1 to 5, B is a single bond or CH.dbd.CH, n is 1 to 4, X is O or ##STR2## wherein n' is 0, 1 or 2, R is H, lower alkyl or alkali metal and R.sup.1 is lower alkyl, arylalkyl, aryl, cycloalkyl, cycloalkylalkyl or lower alkenyl and including all stereoisomers thereof.
The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease and as antiinflammatory agents and analgesics.

REFERENCES:
patent: 4061643 (1977-12-01), Cragoe et al.
patent: 4143054 (1979-03-01), Sprague
patent: 4172839 (1979-10-01), Wissner
patent: 4187236 (1980-02-01), Sprague
patent: 4220594 (1980-09-01), Sprague
patent: 4228180 (1980-10-01), Sprague
patent: 4254044 (1981-03-01), Sprague
patent: 4440781 (1984-04-01), Benecke et al.
"Prostaglandin Synthesis", Bindra et al., Academic Press Inc. (1977), pp. 482-489.

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