Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide
Patent
1983-07-22
1985-06-04
Shapiro, Lionel M.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using tissue cell culture to make a protein or polypeptide
2601125R, C12P 2102, C07C10352
Patent
active
045215146
ABSTRACT:
A process for producing an addition compound of N-benzyloxycarbonyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester and phenylalanine methyl ester. Benzyloxycarbonylation of the amino group of L-aspartic acid by benzyloxycarbonylchloride in the presence of a base and esterification of phenylalanine containing its L-body by methanol in the presence of an acid are carried out and both the reaction solutions are admixed after residual methanol is removed from the esterification reaction solution. A proteolytic enzyme is added to the resulting mixture solution after it is adjusted to have a pH, value, at which no substantial deactivation of the enzyme occurs. The reaction of N-benzyloxycarbonyl-L-aspartic acid and phenylalanine methyl ester is carried out in the solution at a pH, at which the proteolytic enzyme exerts the enzymatic activity to deposit the addition compound which is then recovered.
REFERENCES:
patent: 4165311 (1979-08-01), Isowa et al.
patent: 4284721 (1981-08-01), Oyama et al.
Harada Tsuneo
Irino Shigeaki
Nakamura Masao
Oyama Kiyotaka
Ajinomoto Co. Inc.
Sagami Chemical Research Center
Shapiro Lionel M.
Toyo Soda Manufacturing Co. Ltd.
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