Preparation of asymmetric cyclic ureas using an alkali metal in

Details Preparation of asymmetric cyclic ureas using an alkali metal in Preparation of asymmetric cyclic ureas using an alkali metal in

1998-07-06

1999-12-07

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D24304

Patent

active

05998614&

ABSTRACT:
The present invention describes a method for the preparation of asymmetric N,N'-disubstituted cyclic ureas through the selective monodebenzylation of symmetric N,N'-disubstituted cyclic ureas using a dissolving metal reduction. The intermediates can be alkylated to give compounds which are useful as HIV protease inhibitors for the treatment of HIV infection.

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