Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1995-10-13
1999-12-07
Achutamurthy, Ponnathapura
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
530335, 530334, 530336, 530338, 436 86, 436518, 930 20, A61K 3800, G01N 3300, G01N 33543
Patent
active
059985801
ABSTRACT:
Disclosed is a method for preparing a photosensitive peptide which is capable of being activated or deactivated in a biological system, including the steps of: (a) providing an amino acid including a photolabile molecule; and (b) incorporating the amino acid into a peptide during synthesis, wherein incorporation of the amino acid into the peptide produces a photosensitive peptide. Also disclosed is a method of introducing a photosensitive cleavage site into a synthetic peptide, including synthesizing a synthetic peptide having at least one photolabile amino acid, wherein the photolabile amino acid is positioned within the synthetic peptide so that upon irradiation the synthetic peptide is cleaved.
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Carraway Robert
Fay Frederick F.
Ikebe Mitsuo
Walker Jeffrey
Achutamurthy Ponnathapura
Ponnaluri P.
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