Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Patent
1995-06-07
1999-12-07
Caputa, Anthony C.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
530344, 530350, 530351, 435 691, 435 695, A61K 3800, C07K 200, C07K 100, C12P 2106
Patent
active
05998578&
ABSTRACT:
The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically, the subject invention comprises the cloning of a cDNA synthesized by reverse transcription of poly(A)RNA isolated from adherent human monocytes stimulated with bacterial endotoxin. Human IL-1 is useful to induce the production of IL-2 by activated T-cells; it also acts on B-cells and NK-cells. The subject invention further concerns antibodies that are immunoreactive with human IL-1.beta. proteins.
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Auron Philip E.
Dinarello Charles A.
Rich Alexander
Webb Andrew C.
Wolff, deceased Sheldon M.
Caputa Anthony C.
Massachusetts Institute of Technology
Navarro Mark
New England Medical Center Hospitals Inc.
Trustees of Tufts College
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