Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-10-08
1999-12-07
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514212, 5142335, 514337, 514422, 514443, 540542, 544132, 546202, 546256, 548112, 548575, 549 5, A61K 31445, C07D40910
Patent
active
059984430
ABSTRACT:
This invention relates to the fields of pharmaceutical and organic chemistry and provides novel phosphorous-containing benzothiophene compounds which are useful for the treatment of the various medical indications associated with post-menopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus and cervix. The present invention further relates to intermediate compounds and processes useful for preparing the pharmaceutically active compounds of the present invention, and pharmaceutical compositions.
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Bungaard, H., Design of Prodrugs, Elsevier Science Publishers, pp. 1-10 (1985).
Lombaert, S., et al., J. Med. Chem. 37:498-511 (1994).
Bryant Henry U.
Dodge Jeffrey A.
Nissen Jeffrey S.
Chang Ceila
Eli Lilly and Company
Voy Gilbert T.
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