Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1999-02-23
1999-12-07
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435 911, 435325, 435366, 435455, 536 231, 536 243, 536 2431, 536 2433, 536 245, C07H 2104, C12Q 168, C12N 1500
Patent
active
059982063
ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of G-alpha-12. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding G-alpha-12. Methods of using these compounds for modulation of G-alpha-12 expression and for treatment of diseases associated with expression of G-alpha-12 are provided.
REFERENCES:
Branch TIBS 23:45-50, 1998.
Crooke, S. T. Ch 1 of "Antisense Research & Application", Springer, 1998, pp. 1-50.
Chan, Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product, Mol. Cell. Biol., 1993 13:762-768.
Collins, The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain, Oncogene, 1997, 15:595-600.
Hamm, The many faces of G protein signaling, J. Biol. Chem., 1998, 273:669-672.
Jho, c-Jun amino-terminal kinase is regulated by Galpha12/Galpha13 and obligate for differentiation of P19 embryonal carcinoma cells by retinoic acid, J. Biol. Chem., 1997, 272:24468-24474.
Jho, Galpha12 and Galpha13 mediate differentiation of P19 mouse embryonal carcinoma cells in response to retinoic acid, J. Biol Chem., 1997, 272:24461-24467.
Kozasa, Protein kinase C phosphorylates G12 alpha and inhibits its interaction with G beta gamma, J. Biol. Chem., 1996, 271:12562-12567.
Lin, Galpha12 differentially regulates Na+-H+ exchanger isoforms, J. Biol. Chem., 1996, 271:22604-22610.
Mitsui, Dependence of activated Galpha12-induced G1 to S phase cell cycle progression on both Ras/mitogen-activated protein kinase and Ras/Rac1/Jun N-terminal kinase cascades in NIH3T3 fibroblasts, J. Biol. Chem., 1997, 272;4904-4910.
Needham, Galpha12 and Galpha13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate, J. Biol. Chem., 1998, 273:14626-14632.
Voyno-Yasenetskaya, Galpha12 and Galpha13 regulate extracellual signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells, J. Biol. Chem., 1996, 271:21081-21087.
Voyno-Yasenetskaya, Mutant alpha subunits of G12 and G13 proteins induce neoplastice transformation of Rat-1 fibroblasts, Oncogene, 1994, 9:2559-2565.
Isis Pharmaceuticals , Inc.
LeGuyader John L.
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