Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1998-05-06
1999-12-07
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
424 946, C12N 920, A61K 3846
Patent
active
05998189&
ABSTRACT:
The present invention relates to polypeptide derivatives of dog gastric lipase as obtained by genetic engineering as well as to the nucleotide sequence encoding this recombinant DGL. It also relates to the use of this recombinant DGL for the production of pharmaceutical compositions intended especially for the treatment of pathologies linked to the insufficiency, or even the absence, of secretion of lipases in the body of an individual.
REFERENCES:
patent: 5075231 (1991-12-01), Moreau et al.
Carriere, F., et al., "Purification and biochemical characterization of dog gastric lipase," European Journal of Biochemistry, 1991, vol. 202, pp. 75-83.
Iverson, S.J., et al., "Milk lipid digestion in the neonatal dog; the combined actions of gastric and bile salt stimulated lipascs," Biochemica at Biophysica acta, 1991, vol. 1083, No. 1, pp. 109-119.
Bodmer, M.W. et al. "Molecular cloning of a human gastric lipase and expression of the enzyme in yeast." Biochimica et Biophysica Acta (Aug. 1987), vol. 909, No. 3, pp. 237-244.
Benicourt Claude
Blanchard Claire
Junien Jean-Louis
Crissey Todd M.
Patterson Jr. Charles L.
Warner-Lambert & Company
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