Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-01-17
1999-12-07
Myers, Carla J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 435810, 536 2431, 536 2433, 514 1, C12Q 168, C07H 2104
Patent
active
059981377
ABSTRACT:
A method of diagnosis comprises determining genotype of a TGF-.beta.1 promoter-specific polmorphisms that have been identified are at positions -800bp and -509bp. The genotype determined is then used to assess predisposition or susceptibility to a number of diseases: osteoporosis, atherosclerosis, cancer and immune disorders.
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Kim, S.-J. et al., "Characterization of the Promoter Region of the Human Transforming Growth Factor-.beta.1 Gene," J. Biol. Chem. 264(1):402-408 (1989).
Kim, S.-J. et al., "Promoter Sequences of the Human Transforming Growth Factor-.beta.1 Gene Responsive to Transforming Growth Factor-.beta.1 Autoinduction, " J. Biol. Chem. 264(12):7041-7045 (1989).
Lafyatis, R. et al., "Structural and Functional Characterization of the transforming Growth Factor .beta.3 Promoter," J. Biol. Chem. 265(31):19128-19136 (1990).
Grainger David J.
Heathcote Kirsten
Spector Timothy D.
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