Benzo (b) thiophene carboxylate derivatives and pharmaceutical c

Details Benzo (b) thiophene carboxylate derivatives and pharmaceutical c Benzo (b) thiophene carboxylate derivatives and pharmaceutical c

1986-03-13

1988-04-26

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 57, 549469, 544139, 548180, 548224, 548327, 548334, 548509, 548510, 548466, 514725, 514847, 514863, 514861, 514864, 514880, 514885, 514912, 514914, 514938, 514944, 514962, 514969, 514859, 424 59, 424 60, 424 70, 424 69, 424 47, 424DIG4, A61K 3138, C07D33354

Patent

active

047405198

ABSTRACT:
Aromatic heterocyclic derivatives have the formula ##STR1## wherein R.sub.1 represents ##STR2## wherein R.sub.3 represents hydrogen, --OR.sub.4 wherein R.sub.4 represents hydrogen, alkyl having 1-20 carbon atoms or mono- or polyhydroxyalkyl or R.sub.3 represents ##STR3## wherein r' and r" represent hydrogen, lower alkyl or together form a heterocycle, R.sub.2 represents hydrogen or --CH.sub.3 and Ar represents ##STR4## wherein Z is O or S, ##STR5## wherein R.sub.5 is lower alkyl or ##STR6## wherein R.sub.6 is hydrogen or alkyl having 1-10 carbon atoms and R.sub.7 represents alkyl having 4-12 carbon atoms or cycloalkyl, Y is CH or a nitrogen atom and X represents oxygen, sulfur or --N--R.sub.8 when R.sub.8 represents hydrogen, lower alkyl or lower alkoxycarbonyl, with the proviso that (i) when Y is CH and X is oxygen or sulfur Ar is other than C and (ii) when Y is nitrogen and X is oxygen, Ar is other than (C) or (D) in which R.sub.6 is alkyl having 1-4 carbon atoms and R.sub.7 is branched alkyl having 4-12 atoms useful in veterinary or human therapy and in cosmetic formulations.

REFERENCES:
patent: 4456618 (1984-06-01), Dawson et al.

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