Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-05-27
1988-04-26
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548251, 548252, A61K 3141, C07D25704
Patent
active
047405147
ABSTRACT:
There are described compounds of the formula ##STR1## in which R.sup.1 is hydrogen or C.sub.1-6 alkyl, R.sup.2 is hydrogen, C.sub.1-6 alkyl or C.sub.3-6 alkenyl, X and Y are each oxygen, sulphur, sulphinyl or sulphonyl, n is 2 to 6 and Z is 1H-tetrazol-5-yl, 1H-tetrazol-5-ylthio, 1H-tetrazol-5-ylsulphinyl, 1H-tetrazol-5-ylsulphonyl, cyano or thiocyano, provided that when both X and Y are oxygen Z is 1H-tetrazol-5-ylthio, 1H-tetrazol-5-ylsulphinyl, 1H-tetrazol-5-ylsulphonyl or thiocyano; and salts thereof. The compounds in which Z is other than cyano or thiocyano have pharmaceutical activity and inhibit leukotriene action or formation.
REFERENCES:
patent: 4031236 (1977-06-01), Ahrens et al.
patent: 4372953 (1983-02-01), Uchida et al.
patent: 4567201 (1986-01-01), Nohara et al.
patent: 4585781 (1986-04-01), Bays et al.
Goldsworthy John
Marshall Winston S.
Verge John P.
Conrad Robert A.
Hollrah Glennon H.
Lilly Industries Limited
Springer D. B.
Whitaker Leroy
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