Methyl substituted imidazol-1-yl quinolones

Details Methyl substituted imidazol-1-yl quinolones Methyl substituted imidazol-1-yl quinolones

1986-11-12

1988-04-26

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546157, 548337, 548341, C07D40104, A61K 3147

Patent

active

047405139

ABSTRACT:
A series of novel heterocyclic-substituted 2-(1H)-quinolone compounds have been prepared wherein the heterocyclic ring moiety is a substituted pyrrolyl, imidazolyl, pyrazolyl, triazolyl or tetrazolyl group attached by a nitrogen atom of said group to the 5-, 6-, 7- or 8-positions of the quinolone ring. These particular compounds are useful in therapy as highly potent cardiac stimulants and therefore, are of value in the treatment of various cardiac conditions. Typical member compounds include those 6-(heterocyclic-substituted)-8-methyl-2-(1H)-quinolones wherein the heterocyclic ring moiety is a ring-substituted imidazol-1-yl group and preferably, an imidazol-1-yl group substituted with one or two methyl groups and a monoacetyl group. 6-(4-Acetyl-2-methylimidazol-1-yl)-8-methyl--2-(1H)-quinolone represents a typical and preferred member compound. Methods for preparing all these compounds from known starting materials are provided.

REFERENCES:
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patent: 4258185 (1981-03-01), Nakao et al.
patent: 4277479 (1981-07-01), Nishi et al.
patent: 4284787 (1981-08-01), Knupper et al.
Tominaga et al. English Abstract for WO82/01706 (5/27/82).

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