Process for measuring endotoxin and apparatus used therefor

Details Process for measuring endotoxin and apparatus used therefor Process for measuring endotoxin and apparatus used therefor

1985-06-26

1988-04-26

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

73 641, 422 73, 436502, 436517, 436805, G01N 33579

Patent

active

047404604

ABSTRACT:
Endotoxin contents in samples can be determined qualitatively, or quantitatively, singly or in parallel, with high precision in a short time by a process comprising applying a light to each sample solution, measuring an initial transmitted light amount I.sub.0 and a transmitted light amount at a time t, I(t), to give a ratio R(t)=I(t)/I.sub.0, and judging a gelation point by a threshold value of R(t), or further obtaining a gelation time from the gelation point. An apparatus used therefor is also disclosed.

REFERENCES:
patent: 3458287 (1969-07-01), Gross
patent: 4038029 (1977-07-01), Teller
patent: 4205954 (1980-06-01), Babson
patent: 4224304 (1980-09-01), Sawai
patent: 4268171 (1981-05-01), Sternberg
patent: 4454752 (1984-06-01), Scoraato
patent: 4492462 (1985-01-01), Pross
Search Report from EP 85 10 7877.4.
2200 Medical & Biological Engineering & Computing 22 (1984) Sep., No. 5, Staines, Middlesex, Great Britain, pp. 401-405.
J. Lab. Clin. Med., vol. 75, No. 6, Jun. 1970, pp. 903-911, US; J. Levin et al.: "Detection of Endotoxin in Human Blood and Demonstration of an Inhibitor".

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