Azepine derivatives useful as nitric oxide synthase inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

540484, 540597, C07D22302

Patent

active

058832513

ABSTRACT:
The current invention discloses azepine derivatives useful as nitric oxide synthase inhibitors.

REFERENCES:
patent: 2049582 (1936-08-01), Ziegler
patent: 3109848 (1963-11-01), Bortnick et al.
patent: 3121093 (1964-02-01), Bortnick et al.
patent: 3132151 (1964-05-01), Bortnick et al.
patent: 3501487 (1970-03-01), Poos
patent: 3563994 (1971-02-01), Wollweber et al.
patent: 3694432 (1972-09-01), Hershenson
patent: 3725435 (1973-04-01), Poos
patent: 3816457 (1974-06-01), Grisar et al.
patent: 4046909 (1977-09-01), Rasmussen et al.
patent: 4061746 (1977-12-01), Blohm et al.
patent: 4126613 (1978-11-01), Grisar et al.
patent: 4126621 (1978-11-01), Grisar et al.
patent: 4153235 (1979-05-01), Grisar et al.
patent: 4443468 (1984-04-01), Maillard et al.
patent: 4523020 (1985-06-01), Moormann et al.
patent: 4525476 (1985-06-01), Butler et al.
patent: 4533739 (1985-08-01), Pitzele et al.
patent: 4556674 (1985-12-01), Maillard et al.
patent: 4579951 (1986-04-01), Pitzele et al.
patent: 4699918 (1987-10-01), Maillard et al.
patent: 4855444 (1989-08-01), Wambach
patent: 4962204 (1990-10-01), Wambach
patent: 5015633 (1991-05-01), Sudilovsky
patent: 5028627 (1991-07-01), Kilbourn et al.
patent: 5051444 (1991-09-01), Tamoto et al.
patent: 5059712 (1991-10-01), Griffith
patent: 5081148 (1992-01-01), Braquet et al.
patent: 5132453 (1992-07-01), Griffith
patent: 5196439 (1993-03-01), Sugimoto et al.
patent: 5216025 (1993-06-01), Gross et al.
patent: 5246971 (1993-09-01), Williamson et al.
patent: 5266594 (1993-11-01), Dawson et al.
patent: 5273875 (1993-12-01), Griffith
patent: 5621004 (1997-04-01), Dunn et al.
patent: 5629322 (1997-05-01), Guthikonda et al.
Bertolini et al., "Nitric Oxide Synthase Inhibitors: Recent Advances", Cardiovascular & Renal Patent Update, Ashley Publications Ltd., pp. 1339-1345, 1994.
Culvenor, C.C.J. et al, Aust. J. Chem., 24 (1971) 371-375.
Caujolle, R. et al, Eur. J. Med. Chem. Chim. Ther., 28(1) (1993) 29-35.
Kato et al, Chem. Pharm. Bull., 20 (1972) 901.
Anderson, Wayne K. et al, Synth. Commun., 19(13-14) (1989) 2237-2242.
Olomucki et al, Biochim. Biophys. Acta, 263 (1972) 213-216.
Otake, N. et al, Tetrahedron Lett., 19 (1965) 1411-1419.
Patent: Kerin Seiyaku Kabushiki Kaisya, JP, A, 17189, 1968; Referati vnyi Zhurnal. Khimiya., 1 (1970) N469P.
Umezawa et al, J. Antibiot., 26 (1973) 625, 637.
Bycroft et al., J. Antibiot., 22 (1969) 133-134.
Bycroft et al., J. Chem. Soc. (C), (1971) 3040-3046.
Marconi et al, J. Antibiot., 23 (1970) 120-124.
Kretow et al, J. Gen. Chem. USSR, 32 (1962) 464.
Dorn et al, Chem. Ber., 103 (1970) 2505-2511.
Andrewes et al, Proc. R. Soc. London B, 133 (1946) 20, 53 (Beilstein Registry ID Only).
Schubert, H. W. et al, Arch. Pharm. Ber. Dtsch. Pharm. Ges., 301(10) (1968) 750-762.
Rodricks et al, J. Org. Chem., 36 (1971) 46-48.
Stefanye et al, J. Amer. Chem. Soc., 77 (1955) 761-762.
Goodman et al, J. Org. Chem., 23 (1958) 1954-1956.
Goodman et al, J. Org. Chem., 23 (1958) 1251-1255.
Langlois et al., Synthese de nouvelles amidines bicycliques. 1. Derives de l'imidazole, du triazole-1,3,4 et du tetrazole, J. Heterocyclic Chem., 19(1) (1982) 193-200.
Moncada et al, Biochem. Pharm. 38, 1709-1715 (1989).
Moncada et al, Pharm Rev. 43 109-142 (1991).
S.M. Berge et al, Pharm. Salts, J. Pharm. Sci, 1977 , 66, 1-19.
Perrin et al., "Absence of Stereoelectronic Control in Hydrolysis of Cyclic Amidines", J. Am. Chem. Soc., vol. 108, No. 19, pp. 5997-6003, 1986.
Huber et al., "Saturated Heterocycles, Part 88. Synthesis of a New Ring Perkin Trans. 1, pp. 909-912, 1987.
Kokosi et al., "Nitrogen Bridgehead Compounds. Part 19(1). Synthesis of Polymethylenepyrimidin-4-ones", J. Heterocyclic Chem., vol. 19, pp. 909-912, 1982.
Adcock et al., 2-Amino-2-imidazolines 2-Amino-2-oxazolines, Part II, pp. 474-479, 1965.
Stefanye et al., "Cyclic Guanidines from Nitrimino Compounds", J. Am. Chem. Soc., vol. 77, No. 3, pp. 761-762, 1955.
Klayman et al., "2-Amino-2-thiazoline. VII. Unequivocal Structure Assignment of the Products of the Reaction of 2-Amino-2-thiazoline and Its Analogs with Carbethoxy Isothiocyanate", J. Org. Chem., vol. 39, No. 13, pp. 1819-1823, 1974.
Moriconi et al., "Synthesis and Reactions of Cyclic Amidines", J. Org. Chem., vol. 33, No. 5, pp. 2109-2111, 1968.
Wagenaar et al., "Methodology for the Preparation of N-Guanidino-Modified Arginines and Related Derivatives", J. Org. Chem., vol. 58, No. 1, pp. 4331-4338, 1993.
Gutteridge, "Acylation of 2-Amino-5,5-dimethyl-.increment.-pyrroline 1-Oxide", J. Chem. Soc., (C), pp. 3121-3125, 1971.
Langlois et al., "Synthesis and Antidepressant Properties of 2-Amino-4-phenyl-1-pyrroline Derivatives", Eur. J. Med. Chem., vol. 13, No. 2, pp. 161-169, 1978 (English Summary, p. 169).
Kloer et al. "Synthesis of Substituted 2-Amino-1-pyrrolines, I." Monatshefte fur Chemie, vol. 101, No. 5, pp. 1263-1270, 1970 (English Summary, p. 1263).
Nakane et al., "Novel Potent and Selective Inhibitors of Inducible Nitric Oxide Synthase", Molecular Pharmacology, vol. 47, pp. 831-834, 1995.
Dunbar et al., "Design, Synthesis, and Neurochemical Evaluation of 2-Amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydopyridines and 2-Amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M.sub.1 Muscarinic Receptor Agonists", J. Med. Chem., vol. 37, No. 17, pp. 2774-2782, 1994.
Klotzer et al. "Synthesis of Substituted 2-Aminopyrrolines, II." Monatshefte fur Chemie, vol. 101, No. 6, pp. 1841-1850, 1970 (English Summary, p. 1841).
Klotzer et al. "Acylderivatives of 2-Amino-1-pyrrolines", Monatshefte fur Chemie, vol. 102, No. 2, pp. 627-634, 1971 (English Summary, p. 627).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Azepine derivatives useful as nitric oxide synthase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Azepine derivatives useful as nitric oxide synthase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azepine derivatives useful as nitric oxide synthase inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-818941

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.