Chemotactic assay for immunogenicity

Details Chemotactic assay for immunogenicity Chemotactic assay for immunogenicity

1985-02-28

1987-12-22

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

424 88, 435 29, 435 68, 4351723, 436503, 436543, 436547, 935 60, 935 65, A61K 3900, C12Q 102, C12Q 134, G01N 33531

Patent

active

047146745

ABSTRACT:
The in vitro chemotactic activity of recombinant protein compositions is a predictive test for in vivo immunogenicity. Recombinant synthesis methods and subsequent purification or processing techniques are modified in the light of the chemotactic assay results in order to reduce or enhance the in vivo immunogenicity of the compositions. The invention ameliorates a major cost and source of uncertainty in the development of recombinant protein compositions. Immunogenicity of substances in vivo is modulated by binding chemotactic polypeptides thereto.

REFERENCES:
J. T. Bennett et al, FEBS Letters ll6, 57-61, 1980.
J. D. Watson et al, Recombinant DNA, Scientific American Books, New York, 1983, p. 236.

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