Process for the preparation of 5-fluorotoluene-2,4-disulphochlor

Details Process for the preparation of 5-fluorotoluene-2,4-disulphochlor Process for the preparation of 5-fluorotoluene-2,4-disulphochlor

1986-04-16

1988-04-26

Shippen, Michael L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260505R, C07C14370

Patent

active

047403330

ABSTRACT:
5-Fluorotoluene-2,4-disulphochloride is prepared by chlorosulphonation of 3-fluorotoluene by first reacting the 3-fluorotoluene with chlorosulfuric acid and then with an inorganic acid chloride at temperatures up to 130.degree. C. until the evolution of gas is complete, and then heating the reaction mixture at temperatures of up to 200.degree. C. and, after the completion of the gas evolution, reacting the product at a lower temperature with further inorganic acid chloride, or reacting the 3-fluorotoluene with powerful sulphonating agents at an elevated temperature, if appropriate in the presence of inert solvents and/or diluents, to give the corresponding disulphonic acid and then treating the disulphonic acid with inorganic acid chlorides.

REFERENCES:
Kirk-Othmer, Encyclopedia of Chemical Technology, 2nd., vol. 19, p. 282 and vol. 1, pp. 222-224.
Kirk-Othmer, Encyclopedia of Chemical Technology, Interscience, Publ. 2nd Ed., vol. 19, pp. 293-294, 301 and 313-314, 3rd Ed., vol. 22, pp. 7 and 45-48.
Journal of Pharmacy and Pharmacology, vol. 12, 1960, pp. 419-425, London, GB; B. G. Boggiano et al.: "Studies in the Field of Diuretic Drugs".
Journal of Organic Chemistry, vol. 27, Mar. 1962, pp. 951-956, Easton, U.S.: C. W. Whitehead et al.: "Diuretics. VI. 1,2,4-Benzothiadiazine 1,1-Dioxides Substituted at 2,3,4- and 7-N-Sulfamoyl Positions".

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