Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-02-15
1999-03-16
Stockton, Laura L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548416, 548417, A61K 3140, C07D48714
Patent
active
058831142
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/EP93/01347 filed May 28, 1993.
INDOLOCARBAZOLE IMIDES AND THE USE THEREOF
The present invention is concerned with the use of indolocarbazole imides, some of which are new, for the preparation of pharmaceutical compositions for the treatment and/or prevention of cancer, virus diseases, heart and blood vessel diseases, bronchopulmonary diseases, degenerative diseases of the central nervous system, inflammatory diseases, diseases of the immune system and psoriasis and for use as immune suppressives.
More particularly, the present invention is concerned with the use of indolocarbazole imides of the general formula (I): ##STR2## wherein R.sup.1 and R.sup.2 are the same or different and are in each case, a hydrogen atom, a straight-chained or branched alkyl, alkenyl or alkynyl radical containing up to 6 carbon atoms, an epoxyalkyl radical containing up to 4 carbon atoms, an unsubstituted or substituted aryl or aralkyl radical containing, in each case, up to 12 carbon atoms, a cyano group, a straight-chained or branched cyanoalkyl, cyanoalkenyl, cyanoalkynyl, dicyanoalkyl, dicyanoalkenyl, azidoalkyl, azidoalkenyl, haloalkyl, di- or trihaloalkyl, halohydroxyalkyl, hydroxyalkyl, acyloxyalkyl, dihydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, cyanoalkoxyalkyl, cyanoalkylthioalkyl, isocyanoalkyl, carboxyalkyl, amidinoalkyl, amidinothioalkyl, (2-nitroguanidino)-alkyl, cyanatoalkyl, isocyanatoalkyl, thiocyanatoalkyl or isothiocyanatoalkyl radical, in each case containing up to 6 carbon atoms, an arylsulphonyloxyalkyl or alkylsulphonyloxyalkyl radical containing up to 12 carbon atoms, a straight-chained or branched aminoalkyl group containing up to 12 carbon atoms unsubstituted on the nitrogen atom or mono-, di- or trisubstituted by benzyl radicals or alkyl radicals containing up to 4 carbon atoms or in which two substituents on the nitrogen atom, together with the nitrogen atom or a substituent on the nitrogen atom and a substituent of the alkyl chain and together with the nitrogen atom form a heterocyclic ring containing 3 to 6 carbon atoms which can also contain oxygen, sulphur and/or further nitrogen atoms and can be substituted by alkyl radicals containing up to 4 carbon atoms, whereby the alkyl chain can be substituted by further C.sub.1 -C.sub.4 -alkyl radicals, a hydroxyl group or a C.sub.1 -C.sub.4 -alkoxy radical, an acylaminoalkyl radical containing up to 6 carbon atoms, an alkoxycarbonylalkyl radical containing up to 7 carbon atoms, a radical of the general formula: ##STR3## in which n is 1, 2 or 3 and R.sup.11 and R.sup.12 can be the same or different and, in each case, are a hydrogen atom or an alkyl radical containing up to 6 carbon atoms or an acyl radical containing up to 4 carbon atoms or R.sup.1 and R.sup.2 together signify an alkylene radical containing 2 to 4 carbon atoms which is optionally substituted by a hydroxyl group, an alkoxy radical containing up to 4 carbon atoms or an amino group which is unsubstituted or can be mono- or disubstituted by benzyl radicals or alkyl radicals containing up to 4 carbon atoms and R.sup.3 to R.sup.10, independently of one another, are each a hydrogen atom, a C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, benzyloxy, C.sub.1 -C.sub.4 -acyl, halogen, nitro, hydroxyl, acyloxy, trifluoromethyl, amino, unsubstituted or mono- or disubstituted by benzyl radicals or alkyl radicals containing up to 4 carbon atoms, aminoalkyl or aminoalkoxy containing up to 12 carbon atoms, unsubstituted on the nitrogen atom or mono- or di-substituted by benzyl radicals or alkyl radicals containing up to 4 carbon atoms, hydroxyalkyl containing up to 4 carbon atoms, carboxyl, acylamino containing up to 4 carbon atoms, haloalkyl containing up to 4 carbon atoms, C.sub.1 -C.sub.4 -alkylsulphinyl or alkylsulphonyl, sulpho, carbamoyl, mono- or di-(C.sub.1 -C.sub.4 -alkyl)-carbamoyl or cyano or two neighbouring radicals together stand for a methylenedioxy radical, with the proviso that if R.su
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Aranda Julian
Barth Hubert
Betche Hans Jurgen
Hartenstein Johannes
Kleinschroth Jurgen
Anderson Elizabeth M.
Goedecke Aktiengesellschaft
Stockton Laura L.
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