Antiarrhythmic phenethylpiperidine compounds

Details Antiarrhythmic phenethylpiperidine compounds Antiarrhythmic phenethylpiperidine compounds

1981-07-16

1983-08-16

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424267, C07D21128

Patent

active

043992862

ABSTRACT:
2-Phenethylpiperidines bearing urea, thiourea, and amidine substituents in the ortho-position of the phenethyl moiety have been synthesized and demonstrate useful antiarrhythmic properties. These novel compounds are prepared by reaction of appropriately substituted o-amino-phenethylpiperidines with appropriately substituted phenyl isothiocyanates, phenyl isocyanates, or phenyl imino esters.

REFERENCES:
patent: 3852339 (1974-12-01), Krapto
patent: 3931195 (1976-01-01), Dykstra et al.
patent: 4000143 (1976-12-01), Dykstra et al.
patent: 4007181 (1977-02-01), Ducharme et al.
patent: 4064254 (1977-12-01), Dykstra et al.
patent: 4066695 (1978-01-01), Cohen et al.
patent: 4071524 (1978-01-01), Banitt
patent: 4073790 (1978-02-01), Archibald et al.
Burger Medicinal Chemistry, Third Edition, Part 1, pp. 64 to 79.
Hansch et al., Journal of Medicinal Chemistry 1973, vol. 16, No. 11, pp. 1207-1216 and vol. 19, No. 1, pp. 1-5.
Durant et al., Journal of Medicinal Chem. 1977, vol. 20, No. 7, pp. 901-906.
Chronicles of Drug Discovery, vol. 1, 1982, John Wiley & Sons, Inc., pp. 1-37.
Dykstra et al., Jour. of Medicinal Chem. 16, 1015 (1973).
Byrne et al., The Jour. of Pharmacology and Experimental Therapeutics, vol. 200, No. 1, p. 147, 1977.

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