Process for the optical resolution of mixtures of D- and L-2-(6-

Details Process for the optical resolution of mixtures of D- and L-2-(6- Process for the optical resolution of mixtures of D- and L-2-(6-

1981-07-13

1983-08-16

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562401, C07D45304, C07B 1900

Patent

active

043992846

ABSTRACT:
A new process for the optical resolution of mixtures of d- and 1-2-(6-methoxy-2-naphthyl)-propionic acids, which comprises preparing a solution of a mixture of d-and 1-2-(6-methoxy-2-naphthyl)-propionic acids and an optically active organic base in a predetermined organic solvent, slowly cooling the obtained solution and seeding with crystals of a salt of d-2-(6-methoxy-2-naphthyl)-propionic acid with the optically active organic base containing a certain amount by weight of the organic solvent, and treating the obtained product with mineral acids in suitable organic solvents to obtain the free d-2-(6-methoxy-2-naphthyl)-propionic acid.

REFERENCES:
patent: 3658858 (1972-04-01), Harrison
patent: 3658863 (1972-04-01), Harrison
patent: 3683015 (1972-08-01), Dyson
patent: 3686183 (1972-08-01), Dyson
patent: 3904682 (1975-09-01), Fried et al.
patent: 3988365 (1976-10-01), Gallegra
C.A., vol. 72; 100364 (b), (1970).
C.A., vol. 74; 99717(b), (1971).
C.A., vol. 74; 3438n, (1971).
C.A., vol. 77; 5613b, (1972).
C.A., vol. 77; 88159g, (1972).
C.A., vol. 80; 14781u, (1974).

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