Di-heterocyclic compounds and their use as antiviral agents

Details Di-heterocyclic compounds and their use as antiviral agents Di-heterocyclic compounds and their use as antiviral agents

1987-06-17

1989-06-27

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142288, 5142368, 514326, 514376, 514377, 544 56, 544137, 546209, 548235, 548236, 548237, A61K 3142, C07D41310, C07D41312

Patent

active

048430870

ABSTRACT:
Compounds of the formulas: ##STR1## wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are useful as antiviral agents, especially against picornaviruses. N-(Chloroalkyl)amide intermediates for the compounds of Formula I are also active as antiviral agents. Related compounds outside the scope of the above formulas are also disclosed.

REFERENCES:
patent: 3778445 (1973-12-01), Timmons
patent: 3794725 (1974-02-01), Maier
patent: 3838162 (1974-09-01), Maier
patent: 3945998 (1976-03-01), Anderson
patent: 4268678 (1981-05-01), Diana
patent: 4350519 (1982-09-01), Durr
patent: 4451476 (1984-05-01), Diana

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