Triaryl substituted imidazoles, compositions containing such com

Details Triaryl substituted imidazoles, compositions containing such com Triaryl substituted imidazoles, compositions containing such com

1997-11-17

1999-09-21

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5462741, C07D40104, A61K 3144

Patent

active

059554800

ABSTRACT:
2,4-Diaryl-5-pyridylimidazoles are glucagon antagonists and inhibitors of the biosynthesis and/or action of TNF-.alpha. and IL-1. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose. The instant imidazoles are also inhibitors of TNF-.alpha. and IL-1. Compounds of the present invention may be used for glucagon-mediated as well as cytokine mediated diseases. Cytokine mediated diseases refers to diseases or conditions in which excessive or unregulated production of one or more cytokines occurs. Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) are cytokines produced by a variety of cells, which are involved in immunoregulation and other physiological conditions, such as inflammation.

REFERENCES:
patent: 4608382 (1986-08-01), Ferrini et al.
patent: 5633377 (1997-05-01), Thurkauf et al.
patent: 5656644 (1997-08-01), Adams et al.

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