Antibacterial analogs of isocephalosporins

Details Antibacterial analogs of isocephalosporins Antibacterial analogs of isocephalosporins

1978-06-22

1979-10-16

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D26534

Patent

active

041714393

ABSTRACT:
There is described the stereoselective total synthesis of novel .DELTA..sup.2,3 -1,4-morpholine-2-carboxylic acids possessing a fused .beta.-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein Z is halo or hydroxyl and X is acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

REFERENCES:
patent: 4011216 (1977-03-01), Menard et al.
patent: 4065622 (1977-12-01), Horning et al.
patent: 4066832 (1978-01-01), Menard et al.
patent: 4068066 (1978-01-01), Horning et al.
patent: 4068075 (1978-01-01), Menard et al.
patent: 4068078 (1978-01-01), Menard et al.
patent: 4068080 (1978-01-01), Menard et al.
patent: 4112230 (1978-09-01), Menard et al.
patent: 4118566 (1978-10-01), Menard et al.
Cama et al., J. Am. Chem. Soc., vol. 96, pp. 7582-7584, (1974).
Firestone et al., J. Med. Chem., vol. 20, pp. 551 to 556 (1977).
Brunwin et al., J. Chem. Soc. (c), pp. 3756 to 3762 (1971).
Brunwin et al., J. Chem. Soc., Perkins I, pp. 1321-1328, (1973).

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