Anthracycline derivatives as solubilized pro-drugs

Details Anthracycline derivatives as solubilized pro-drugs Anthracycline derivatives as solubilized pro-drugs

1992-03-09

1993-05-18

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 34, C07H 1524

Patent

active

052122913

ABSTRACT:
The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guanidine, isourea, isothiourea and biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phosphoric acid.

REFERENCES:
patent: 4185111 (1980-01-01), Ducep et al.
patent: 5001115 (1991-03-01), Sloan

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