Composition and process

Details Composition and process Composition and process

1980-12-22

1983-12-13

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

260404, 562466, 562501, 2604045, 564 88, 564 89, 260408, 564 91, 564 96, 260410, 564 97, 564 98, 2604109R, 564 99, 564152, 260413, 564158, 564159, 260464, 564172, 564188, 260465D, 564428, 564454, 424263, 568633, 568734, 424275, 568819, 424285, 424305, 424308, 424317, 424320, 424321, 424324, 424325, 424330, 424343, 542421, 542429, 549 79, 549501, 560 12, 560 39, 560 45, 560 56, 562501, 562427, 562444, 562455, C07C17700, C07C 5726

Patent

active

044206321

ABSTRACT:
The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet antiaggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.

REFERENCES:
patent: 4057571 (1977-11-01), Grudzinskas
Stork, J. Am. Chem. Soc. 98, 1583 (1976).

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