Derivatives of amide analogs of certain methano bridged quinoliz

Details Derivatives of amide analogs of certain methano bridged quinoliz Derivatives of amide analogs of certain methano bridged quinoliz

1998-10-29

1999-09-21

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142305, 514243, 514278, 546 18, 546 94, 544105, 544183, A61K 3144, A61K 3153, C07D45500, C07D26536

Patent

active

059554703

ABSTRACT:
This invention relates to novel amide derivatives of certain 2,6-methano-2H-quinolizine-type compounds, to the intermediates and processes for their preparation, to their ability to antagonize the effects of serotonin at the 5HT.sub.3 receptors, and to their end-use application in the treatment of chemotherapeutically-induced nausea and vomiting, as anti-anxiety agents, in the symptomatic treatment of pain associated with migraine, as anti-arrhythmic agents, in the treatment of cognitive disorders, in treating hallucinatory endogenous psychoses of the type manifested in patients suffering from schizophrenia, and mania, in the treatment of glaucoma, for stimulating gastric motility, to combat drug abuse, to treat sleep apnea and to treat irritable bowel syndrome.

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