Psychotropic piperidinylmethyl benzodioxans

Details Psychotropic piperidinylmethyl benzodioxans Psychotropic piperidinylmethyl benzodioxans

1992-05-13

1993-05-18

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 5142265, 514278, 514279, 514281, 514321, 514323, 514410, 514422, 540520, 540596, 540597, 540599, 540602, 544 49, 548424, 548526, 546 16, 546 39, 546197, 546200, A61K 3155, A61K 3154, A61K 3144, A61K 31445, A61K 3140, C07D48700, C07D27916, C07D

Patent

active

052121704

ABSTRACT:
The compounds ##STR1## in which Z is ##STR2## where R.sup.4 is --H or alkyl; q is one of the integers 0, 1 or 2; Y is H.sub.2 or O; or Z, taken with R.sup.1 forms ##STR3## R.sup.1 is hydrogen or alkyl or combined with Z as described above; R.sup.2 and R.sup.3 are, independently, hydrogen, alkyl, alkoxy, aralkoxy, alkanoyloxy, hydroxy, halo, amino, mono- or dialkylamino, carbamoyl or sulfonamido or R.sup.2 and R.sup.3, taken together are methylenedioxy, ethylenedioxy or propylenedioxy; m is one of the integers 1, 2 or 3; n is one of the integers 0 or 1; or a pharmaceutically acceptable salt thereof are antipsychotic, antidepressant and anxiolytic agents useful in relieving the symptoms of these disease states.

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Fozard et al., Br. J. Pharmacol., 90, 273P (1987).
Caroon et al., J. Med. Chem. 24 1320-1328 (1981).

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