Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1978-02-16
1979-10-16
Schwartz, Gerald A.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260564A, C07C12508, C07C13310
Patent
active
041713257
ABSTRACT:
Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines and thioureas by treating a heterocyclicalkyl derivative with a mercaptoalkyl-N-cyanoguanidine or thiourea. Two specific products are N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]guanidine and N-methyl-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiourea, both useful as histamine H.sub.2 -antagonists.
REFERENCES:
patent: 2345388 (1944-03-01), Ericks et al.
patent: 2910497 (1959-10-01), Meuly
Chemical Abstracts, vol. 46, col. 3,804, (g), (1952).
Wilson et al., "Textbook of Organic Medicinal and Pharmaceutical Chemistry," pp. 38-40, (1966).
Brown Thomas H.
Durant Graham J.
Emmett John C.
Ganellin Charon R.
Edgerton William H.
Foggio Richard D.
Keps Joan S.
Schwartz Gerald A.
Smith Kline & French Laboratories Limited
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