Construction and expression of synthetic genes encoding envelope

Details Construction and expression of synthetic genes encoding envelope Construction and expression of synthetic genes encoding envelope

1994-10-21

1997-12-02

Smith, Lynette R. F.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 691, 435 723, 43525233, 435 5, 4242071, C07K 100, C12Q 170, C12P 2106, C12N 120

Patent

active

056937555

ABSTRACT:
A synthetic gene which codes for at least one epitope from the immunodominant conserved region of HTLV-I env. gp 21 as well as hybrid genes utilizing the synthetic gene in conjunction with other epitopes from HTLV-Ienv. gp 46 and gp 21; the corresponding gene products, recombinant vectors containing the genes, methods for producing the polypeptides and methods for detecting antibodies to HTLV-I using the polypeptides of the invention

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patent: 4939094 (1990-07-01), Kuga et al.
patent: 5003043 (1991-03-01), Akita et al.
Copeland et al., The Journal of Immunology, 137:2945-51 (Nov. 1, 1986).
Samuel et al., Science, 226:1094-97 (Nov. 30, 1984).
Copeland et al., Biochem. and Biophys. Res. Comm. 126:672-77 (Jan. 31, 1985).
Seiki, et al., 1983 "Human Adult T Cell Leukemia virus . . . " PNAS 80: 3618-3622.
Yoshida, et al., 1982 "Isolation and characterization of retrovirus . . . " PNAS 79:2031-2035.

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