Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-07-28
1999-09-21
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530300, 530304, 530324, A61K 3800
Patent
active
059554282
ABSTRACT:
The present invention provides a human metallothionein (HMBP-I) and polynucleotides which identify and encode HMBP-I. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HMBP-I and a method for producing HMBP-I. The invention also provides for agonists, antibodies, or antagonists specifically binding HMBP-I, and their use, in the prevention and treatment of diseases associated with expression of HMBP-I. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HMBP-I for the treatment of diseases associated with the expression of HMBP-I. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HMBP-I.
REFERENCES:
Schmidt, C.J. et al., "Cloning and sequence analysis of two monkey metallothinein cDNAs", Gene, 24: 137-146 (1983).
Schmidt, C.J. et al., "Structure and expression of two human metallothionein-I isoform genes and a related pseudogene", J. Biol. Chem., 260: 7731-7737 (1985).
Soumillion, A. et al., "Cloning and specific polymerised-chain-reation amplification of a third charge-separable human metallothionein isoform", Eur. J. Biochem., 209: 999-1004 (1992).
Heguy, A. et al., "Structure and tissue-specific expression of the human metallothionein I.sub.b gene", Molecular and Cellular Biology, 6: 2149-2157 (1986).
Reeck, G.R., et al., ""Homology" in Proteins and Nucleic Acids: A Terminology Muddle and a Way out of It", Cell, 50: 667 (1987).
Varshney, U. and L. Gedamu, "Human metallothionein MT-I and MT-II processed genes", Gene, 31: 135-145 (1984).
Schmidt, C.J. and D.H. Hamer, (Direct Submission), GenBank Sequences Database (Accession K00484), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 342384) (1989).
Varshney, U. and L. Gedamu, (Direct Submission), GenBank Sequence Database (Accession M13073), National Center Ford Biotecnnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 187552) (1986).
Matsubara, K. et al., (Direct Submission), GenBank Sequence Database (Accession T20977), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 2756896) (1996).
Okubo, K. et al. (Direct Submission), GenBank Sequence Database (Accession C21221), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1622331) (1996).
Foster et al. (1988) J. Biol. Chem. 263/23 pp. 11528-11535, 1988.
Foster et al. (1989) GenBank Database, Accession No. A29236, 1989.
Goli Surya K.
Hillman Jennifer L.
Incyte Pharmaceuticals Inc.
Longton Enrique D.
Wax Robert A.
LandOfFree
DNA encoding human metallothionein does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with DNA encoding human metallothionein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding human metallothionein will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-80235