Process of preparing enriched enantiomers of glycerol carbonate

Details Process of preparing enriched enantiomers of glycerol carbonate Process of preparing enriched enantiomers of glycerol carbonate

1993-10-21

1994-07-05

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31708

Patent

active

053268857

ABSTRACT:
Enriched enantiomers of glycerol Carbonate are produced under the influence of a hydrolytic enzyme, either by selective esterification of racemic glycerol carbonate or by selective hydrolysis of an ester of the racemate. The enriched enantiomeric product is readily converted to starting materials and intermediates useful in the synthesis of enantiomerically pure therapeutic agents, such as .beta.-adrenergic blockers.

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Thomas Walle, et al, "Stereoselective Delivery and Actions of Beta Receptor Antagonists", Biochemical Pharmacology, vol. 37, No. 1, 1988, pp. 115-124.

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