Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazol

Details Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazol Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazol

1992-07-17

1994-07-05

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514542, 514369, 546153, 546155, 546156, 546157, 546159, 546168, 546169, 546170, 546172, 546174, 546175, 546178, 546180, 546280, 548183, 548181, A61K 3147, A61K 31425, C07D21516, C07D21538, C07D21518, C07D27704

Patent

active

053267702

ABSTRACT:
This invention relates to monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazolidinediones, such as Formula I, to pharmaceutical compositions thereof, process of preparation, and methods of use in mammals to treat cognitive disorders, neurological dysfunction, and/or mood disturbances such as, but not limited to degenerative nervous system diseases. ##STR1##

REFERENCES:
patent: 3705153 (1972-12-01), Kaneko et al.
patent: 5002953 (1991-05-01), Hindley
Gates, K. S. and Silverman, R. B., J. Am. Chem. Soc., 1990, 112:9364-9372.
Tipton, et al., Biochem. J., 1983, 209:235-242.
Dostert, et al., J. Pharm. Pharmocol., 1984, 9:585-586.
Sohda, T., et al., Chem. Pharm. Bull., 1991, 39:1440-1445.
Sohda, T., et al., Chem. Pharm. Bull., 1982, 30:3580.

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