(S)-1-[(10-chloro-6,7-dih ydro-4-oxo-3-phenyl-4H-benzo[a]quino-l

Details (S)-1-[(10-chloro-6,7-dih ydro-4-oxo-3-phenyl-4H-benzo[a]quino-l (S)-1-[(10-chloro-6,7-dih ydro-4-oxo-3-phenyl-4H-benzo[a]quino-l

1993-03-24

1994-07-05

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514923, 546 95, A61K 31435, C07D22104

Patent

active

053267699

ABSTRACT:
The compound (S)-1-[(10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quino-lizin-1-yl)c arbonyl]-3-ethoxypyrrolidine of the formula ##STR1## which has valuable pharmacological properties, is described. In particular, the compound of formula I has a non-sedating, hypnotic, that is, sleep-promoting, activity and can accordingly be used for the treatment of sleep disorders.

REFERENCES:
patent: 4889848 (1989-12-01), Fischer et al.
Fischer et al., "Tricyclic pyridine derivatives with high affinity to the central benzodiazepine receptor", Helv. Chim. Acta 73:763-781 (1990).
Tamasawa et al., "Stereoselectivity of a potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4 -(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate", J. Med. Chem. 29:2504-2511 (1986).
Bhat et al., "Synthetic routes to chiral 3-pyrrolidinols", Synth. Comm. 15:587-598 (1985).
Scherschlicht et al., "Effects of oral and intravenous midazolam, triazolam and flunitrazepam on the sleep-wakefulness cycle of rabbits", Br. J. Clin. Pharmac. 16:29S-35S (1983).
Chemical Abstracts Service, CA 107:134200, 1986.

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