Method for the dehydration of amides to nitriles

Details Method for the dehydration of amides to nitriles Method for the dehydration of amides to nitriles

1996-10-22

1998-10-06

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

558312, 548236, C07D26334, C07D21178, C07C25300

Patent

active

058178279

ABSTRACT:
The present invention relates to a process for the dehydration of amides to nitrites which comprises carrying out the dehydration in the presence of an adduct of sulphur trioxide and an amine as the dehydrating reagent in a basic reaction mixture. Thereby, for example, aliphatic, aromatic and heteroaromatic amides are dehydrated to the corresponding nitrites, such as 5-carbamoyl-4-methyl-oxazole to 5-cyano-4-methyl-oxazole, a valuable intermediate in the synthesis of pyridoxine.

REFERENCES:
patent: 2783264 (1957-02-01), Klapproth et al.
patent: 4908452 (1990-03-01), Claremon
T. Rinderspacher and B. Prijs, Helv. Chim. Acta, 43, 1960, pp. 1522-1530.
Soviet Inventions Illustrated, Section Ch, Week 8243, Dec. 8, 1982.
Chemical Abstracts, vol. 86, No. 1, Jan. 3, 1977.

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