Phosphatidylinositol 4,5-bisphosphate 5-phosphatase

Details Phosphatidylinositol 4,5-bisphosphate 5-phosphatase Phosphatidylinositol 4,5-bisphosphate 5-phosphatase

1997-06-27

1999-09-21

Hobbs, Lisa

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 6, 4352523, 43525411, 435325, 4353201, 536 232, 536 243, C12N 916, C12N 120, C12N 1500, C07H 2104

Patent

active

059553383

ABSTRACT:
The invention provides a human phosphatidylinositol 4,5-bisphosphate 5-phosphatase (PBPP) and polynucleotides which identify and encode PBPP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PBPP.

REFERENCES:
Rath Hope, H.M. et al., "Purification and characterization of a polyphosphoinositide phosphatase from rat brain." J. Biol. Chem. (1994) 269:23648-23654.
Jefferson, A.B. et al., "Properties of Type II Inositol Polyphosphate 5-Phosphatase." J. Biol. Chem. (1995) 270:93709377. (GI 1019103).
Nussbaum, R.L., (GI 1399104), GenBank Sequence Database (Accession U45975), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Nussbaum, R.L. et al., (GI 1420919), GenBank Sequence Database (Accession U57627), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. (GI 1420920).
Matzaris, M. et al., "Indentification and characterization of the phosphatidylinositol-(4,5)-bisphosphate 5-phosphatase in human platelets." J. Biol. Chem. (1994) 269:3397-3402.
Nussbaum et al. Human phosphatidylinositol (4,5) bisphosphate 5-phosphatase homolog mRNA, partial cds., EST Accession Number U45973, release date Jul. 1, 1996.

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