Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1992-04-30
1994-07-05
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424423, 424424, 6048901, 6048921, 623 11, A61F 202, A61K 922
Patent
active
053265688
ABSTRACT:
The method of tissue-specific delivery of therapeutic agents via a bio-oncotic pump which includes the steps of furnishing an implantable element which is biodegradable in situ within human tissue. Such an element defines a series of respective concentric shells having different therapeutic agents disposed upon each of the shells such that the outermost shell and associated agents will be delivered earliest, while the innermost shell and its agents will be delivered last. The material of the biodegradable element is selected from the group of materials including processed sheep dermal collagen, Hench's bioglass, fibrinogen, polyimino-carbonate, and polylactic acid. A vaso-inductive agent is integrated into the surface of the element. Selected groups of therapeutic agents are incorporated into the element, which is followed by the subcutaneous implantation and securing of said element into the human tissue at the site of interest. Following implantation of the element, the vaso-inductive agent will stimulate capillary growth to facilitate delivery of the therapeutic agent to the tissue specific site.
REFERENCES:
patent: 3625214 (1971-12-01), Higuchi
Azpuru C.
Page Thurman K.
Silverman M. K.
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