Certain aryl fused imidazopyrimidines; a new class of GABA brain

Details Certain aryl fused imidazopyrimidines; a new class of GABA brain Certain aryl fused imidazopyrimidines; a new class of GABA brain

1997-04-25

1998-10-06

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544117, C07D47104

Patent

active

058178139

ABSTRACT:
The present invention encompasses structures of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## and W, X, A, B, C, D, E, R.sub.3, R.sub.4 are variables. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.

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