Production of .alpha.-chloro-.alpha.-oximino-4-hydroxyacetopheno

Details Production of .alpha.-chloro-.alpha.-oximino-4-hydroxyacetopheno Production of .alpha.-chloro-.alpha.-oximino-4-hydroxyacetopheno

1989-02-14

1990-03-20

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Hydroxamic acid halides or chalcogen analogs therof

564258, C07C 8310

Patent

active

049103385

ABSTRACT:
.alpha.-chloro-.alpha.-oximino-4-hydroxyacetophenone is prepared by reacting 4-hydroxyacetophenone with an alkyl nitrite and hydrogen chloride wherein the amount of hydrogen chloride is carefully controlled to limit the amount thereof to about 0.1 to 6 moles of hydrogen chloride per mole of 4-hydroxyacetophenone until at least one equivalent of the alkyl nitrite is reacted. Subsequent to the reaction of the one equivalent of alkyl nitrite, at least 1 mole of hydrogen chloride per mole of initially charged 4-hydroxyacetophenone is added to the reaction medium.

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