Process for preparing doxorubicin

Details Process for preparing doxorubicin Process for preparing doxorubicin

1997-07-28

1999-09-21

Railey, II, Johnny F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

4352523, 43525235, 4353201, C12P 1956, C12N 121, C12N 1563, C12N 1576

Patent

active

059553197

ABSTRACT:
The present invention concerns a process for improving doxorubicin production by means of a recombinant Streptomyces peucetius strain bearing a mutation in the gene dnrU coding for a protein involved in the metabolism of daunorubicin.

REFERENCES:
Stutzman-Engwall et al., Proc. Natl. Acad. Sci. USA 86:3135-3139 (1989).
Otten et al., J. Bacteriol. 172(6):3427-3434 (1990).
Dickens et al., J. Bacteriol. 178(11):3389-3395 (1996).
Scotti et al., J. Bacteriol. 178(24):7316-7321 (1990).

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