Piperidine opioid antagonists

Details Piperidine opioid antagonists Piperidine opioid antagonists

1992-09-03

1994-06-07

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546236, 546237, C07D21122, C07D21120

Patent

active

053190874

ABSTRACT:
This invention provides trans-3,4 1-substituted-3-substituted-4-methyl-4-(3-substituted phenyl)piperidines as opioid antagonists capable of blocking the mu or kappa receptors in the brain.

REFERENCES:
patent: 3991199 (1976-11-01), Berger
patent: 4081450 (1978-03-01), Zimmerman
patent: 4141980 (1979-02-01), Berger
patent: 4191771 (1980-03-01), Zimmerman
patent: 4581456 (1986-04-01), Barnett
Leander et al., European Journal of Pharmacology, 81, 185-192.
Leander et al., Drug Development Research, 4:421-427 (1984).
Leander, The Journal of Pharmacology and Experimental Therapeutics, vol. 224, No. 1, 89-94 (1983).
Zimmerman et al., Nature, vol. 275, Sep. 28, 1978, pp. 332-334.

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