Method of modifying the lipid structure and function of cell mem

Details Method of modifying the lipid structure and function of cell mem Method of modifying the lipid structure and function of cell mem

1987-02-13

1990-03-20

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514572, A61K 3120

Patent

active

049102249

ABSTRACT:
The invention is concerned with the use of certain fatty acids and inhibitors of an enzyme in effecting modifications to the lipid structure of cell membranes. The invention also relates to the formulation of pharmaceutical compositions and medicaments and to such products per se; to the treatment of a variety of clinical and veterinary disorders associated with a lowering of the saturation index of cell membranes, including malignancies, viral disorders and AIDS; and to the use of the active materials of the invention in the relief of pain.
The active principals in the present invention are saturated fatty acids having from 12 to 28 carbon atoms in the alkyl chain, e.g. stearic acid, or pharmaceutically acceptable derivatives thereof; and inhibitors of the enzyme .DELTA.-9 desaturase, e.g. sterculic acid and malvalic acid or pharmacologically active derivatives or analogues thereof.

REFERENCES:
patent: 3741204 (1973-06-01), Thiele
patent: 3805776 (1974-04-01), Thiele
patent: 3856976 (1974-12-01), Hunter et al.
patent: 3993775 (1976-11-01), Williams
patent: 4097602 (1978-06-01), Silver et al.
patent: 4273763 (1981-06-01), Horrobin
patent: 4302447 (1981-11-01), Horrobin
patent: 4386072 (1983-05-01), Horrobin
patent: 4388324 (1983-06-01), Horrobin

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